Journal / Weight loss

Do GLP-1s cause muscle loss?

How to keep lean mass while losing weight on semaglutide or tirzepatide.

GLP-1 medicines reduce appetite, and fast weight loss can include some lean mass. Eating enough protein (about 1.2–1.6 g per kg), lifting weights two to three times a week and losing weight at a steady pace all help protect muscle.

Your clinician can also check body composition and labs along the way, and adjust your dose if needed.

Educational content only — not medical advice. Treatments require a physician review.