The Science
Epigenetics, without the mysticism.
Your DNA is fixed. How it's expressed is not. DNA methylation marks shift with training, sleep, nutrition, stress and medication, and they can be read with laboratory precision. That's what makes biological age measurable, and improvable.
What methylation is
Dimmer switches on your genes.
Small chemical tags called methyl groups sit on your DNA and act like dimmer switches, turning genes up or down without changing the code itself. As you age, and as you live, the pattern of those switches drifts in predictable ways. Poor sleep, chronic stress and inflammation push the drift one way; training, good nutrition and effective therapeutics can slow it or push it back. Epigenetic clocks are models trained on thousands of people that read this drift across hundreds of thousands of sites and translate it into ages and rates you can act on. Because the marks respond to what you do, the numbers are not a verdict. They are a baseline you can measure against.
The clocks in your report
| Clock | Developed with | What it measures |
|---|---|---|
| OMICmAge | Harvard | Whole-body biological age |
| SymphonyAge | Yale and Columbia | Age of 11 organ systems |
| DunedinPACE | Duke | Current pace of aging |
Evidence it responds
Used in 120+ interventional trials.
GLP-1 medications
Studies report favorable shifts in pace-of-aging metrics within months of starting GLP-1 therapy.
Statins
Research suggests statin use may prevent pace-of-aging from worsening over time.
Stanford twin study
Identical twins on different diets showed measurable differences in epigenetic age markers after eight weeks.
Senolytic pilots
Early pilot studies used these clocks to track the biological effect of senolytic protocols.
Yale 51-intervention analysis
A broad analysis compared dozens of interventions on the same epigenetic measures.
Full publication list: research library ↗
Honesty box
What these tests do not do.
They do not diagnose disease. They estimate risk patterns, and they work best measured over time. We would rather say that plainly than oversell a number.