Your appetite and sleep are wired together. When sleep is short, hunger hormones rise and willpower loses. We quiet appetite first, repair sleep second, and protect muscle throughout.
Priorities, in order
01Fix sleep before chasing the scale
02Protein at 0.7g per lb goal weight
03Start GLP-1 while labs process
Foundations
—7+ hours in bed
—Resistance training 2x/week
—Protein at every meal
Start today — no labs needed
✓Semaglutide starter dose (no labs needed)
✓Sleep and protein routine
03What helps & how
What's in it, in plain language.
Foundationinjectable
Tirzepatide
Acts on two satiety hormones (GLP-1 and GIP) for stronger appetite control and better insulin sensitivity.
What to expect: Often faster loss than GLP-1 alone; nausea early is common.
Evidence: Strong (RCTs)
Metabolic flexibilityinjectable
MOTS-c
A mitochondria-derived peptide that improves how muscles use glucose for energy.
What to expect: More sustained energy and exercise tolerance.
Evidence: Emerging
Cellular energyinjectable
NAD+
A coenzyme every cell needs to turn food into energy; levels fall with age.
What to expect: Energy and mental clarity within days of a loading phase.
Evidence: Moderate
04The protocol
Your plan, week by week.
WK 1–4
Tirzepatide
2.5 mg typicalRange 2.5 mgWeekly
Changes when: Tolerating well
WK 5–12
Tirzepatide
5 mg typicalRange 5–7.5 mgWeekly
Changes when: Loss under 0.5%/week
WK 1–8
MOTS-c
5 mg typicalRange 5–10 mg2x weekly
Changes when: Energy improving
WK 1–12
NAD+
100 mg typicalRange 50–200 mg2x weekly
Changes when: Physician review
Acute phase
Titration: weeks 1–8
Long-term
Maintenance at lowest effective dose
Review cadence
Every 4 weeks with your physician
Labs we look at — optimal ranges, not just "normal"